Product Overview
UC-II® is a patented, undenatured (native) type II collagen ingredient, most commonly sourced from chicken sternum cartilage and processed under low-heat conditions specifically to preserve its natural molecular structure. This distinguishes it from hydrolyzed collagen peptides, which are broken down through high-heat and enzymatic processing. Because UC-II® retains its native structure, it is formulated at much lower doses per capsule (typically in the tens of milligrams) than hydrolyzed collagen products, which are often dosed in grams.
Undenatured type II collagen is generally understood to work through a different mechanism than hydrolyzed collagen — it is theorized to interact with immune tissue in the gut related to joint cartilage, rather than acting as a raw material the body rebuilds cartilage from directly.* This makes UC-II® a distinct positioning option within the broader joint-support and collagen categories.*
How Brands Use UC-II® Type II Collagen
- Low-dose, once-daily joint-comfort capsules as an alternative to gram-dosed hydrolyzed collagen
- Standalone joint SKUs or combined with glucosamine, chondroitin, or MSM
- Positioned for consumers who want a smaller pill/capsule size with a targeted joint claim
- Marketed toward active adults and seniors focused on mobility and flexibility
- Formulated as a differentiated "clinically studied ingredient" line extension
Because UC-II® is dosed so differently from hydrolyzed collagen, it's important for private label brands to be clear in their marketing about which type of collagen ingredient is in the formula and how it differs from a typical collagen peptide powder. Our team can help you position UC-II® correctly relative to any hydrolyzed collagen products already in your line.
Health Genesis manufactures UC-II® Type II Collagen capsules at our family-owned, FDA-registered, GMP-certified, and NSF-certified facility in Davie, Florida. With more than 25 years of formulation experience, low minimum order quantities, and in-house label design, we help brands add a differentiated joint-support product to their lineup without a large minimum commitment.
How is UC-II® different from the hydrolyzed collagen in my other products?
UC-II® is undenatured (unhydrolyzed) type II collagen dosed in small milligram amounts, while hydrolyzed collagen peptides are broken down and typically dosed in grams; they are formulated and marketed differently, and many brands offer both as separate products.
What is the typical capsule dose for UC-II®?
Undenatured type II collagen formulas are generally dosed at a low daily milligram amount rather than a gram-scale serving; our formulation team can confirm potency options for your specific product.
Do you provide documentation on sourcing and manufacturing for private label buyers?
Yes, we can provide certificates of analysis and relevant sourcing information for the collagen ingredient used in your formula so your team can verify quality and compliance.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Additional Information
Why Choose Health Genesis
Industry-Leading Private Label Supplement Manufacturing
FDA-Registered & GMP-Certified
Health Genesis operates a fully FDA-registered, GMP-compliant manufacturing facility. Every product undergoes rigorous testing at multiple stages.
Low Minimum Order Quantities
Our accessible MOQs make private label supplements feasible for emerging brands. Test market demand without committing to massive inventory.
Fast Turnaround Times
Our efficient production processes deliver your products quickly. Most orders ship within 2-4 weeks after approval.
Complete Private Label Services
From formulation consultation to fulfillment, we handle everything. Focus on growing your brand while we handle manufacturing.
Quality You Can Trust
Every batch undergoes comprehensive testing: identity, purity, potency, heavy metals, and microbial testing. Third-party lab results available.
Expert Support Team
Our experienced team guides you through label design, regulatory compliance, and production. We're here to help you succeed.

