Find Our Booth #7459 at SupplySide West | October 27-30, 2025
Find Our Booth #7459 at SupplySide West | October 27-30, 2025
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Prescription GLP-1 medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have revolutionized weight management in the United States. By reducing appetite and slowing digestion, these medications often lead to lower food intake and significant weight loss. However, this dramatic shift in eating patterns creates nutritional challenges that companion supplements can effectively address.
In 2025, the supplement industry is recognizing a critical opportunity: not to replace GLP-1 medications, but to support the millions of Americans using them. For brands exploring private label supplements in this space, understanding the difference between compliant companion products and risky “replacement” claims is essential.
Some media headlines have promoted berberine and other botanicals as “Nature’s Ozempic,” but this positioning creates serious compliance risks. No botanical or nutrient mimics the complex mechanism of prescription GLP-1 medications, and making drug-like claims can trigger FDA and FTC enforcement action.
The smart, compliant opportunity lies in GLP-1 companion supplements: products that address specific nutritional needs during weight loss therapy without claiming to replace medications.
Rapid weight loss often results in lean muscle loss alongside fat loss. High-quality protein powder becomes essential for preserving muscle mass during calorie restriction.
Protein solutions for GLP-1 users:
Private label protein manufacturers can create specialized formulations with 20-30g protein per serving, optimized for reduced appetite windows. Consider adding digestive enzymes to enhance absorption when stomach capacity is limited.
Constipation is one of the most common side effects of GLP-1 medications due to slower gastric emptying. Fiber supplements address this while supporting healthy blood sugar levels and prolonged satiety.
Effective fiber options:
Brands working with supplement formulation companies should focus on palatable, easy-to-mix fiber powders or convenient capsule formats.
Reduced fluid intake, combined with potential nausea, can lead to dehydration and electrolyte imbalances. Electrolyte supplements are becoming daily essentials for many GLP-1 users.
Key electrolytes to include:
Stick packs and single-serve powders offer convenient, on-the-go hydration solutions. Private label powder supplements in this category should prioritize clean ingredients and natural flavoring.
When overall food consumption drops by 30-50%, meeting daily vitamin and mineral requirements becomes challenging. Comprehensive multivitamin formulations prevent deficiencies during extended GLP-1 therapy.
Priority micronutrients:
Custom supplement formulation can create GLP-1-specific multivitamins with higher concentrations of commonly deficient nutrients. Consider liquid or gummy vitamin formats for users experiencing pill fatigue.
Slower digestion and altered gut motility make digestive comfort a priority. Probiotic supplements and digestive enzymes can significantly improve user experience.
Digestive support options:
Working with a probiotic supplier or custom supplement manufacturer, brands can create shelf-stable formulations with clinically studied strains.
Major retailers are beginning to dedicate shelf space to “GLP-1 Support” or “Weight Loss Wellness” sections, grouping protein, hydration, fiber, and digestive aids together. Industry analysts project this companion category could reach $2-3 billion as prescription GLP-1 use continues expanding.
For brands entering this space, success requires:
✓ Clear positioning as companion support, not medication alternatives
✓ Educational content that explains why these supplements matter
✓ Clean formulations with transparent labeling
✓ Third-party testing and quality certifications
✓ Compliance-first messaging using only structure/function claims
This category will face heightened regulatory scrutiny. To build sustainable brands:
Amazon’s updated supplement testing requirements make third-party validation crucial. Partner with manufacturers who provide COAs (Certificates of Analysis) and can support NSF, Informed Choice, or USP certification.
At Health Genesis, we specialize in helping brands navigate emerging categories with both innovation and compliance. Our private label supplement capabilities for GLP-1 companion products include:
As a contract supplement manufacturing partner, we understand the importance of timing in fast-growing categories. Our streamlined processes help you launch GLP-1 companion products while demand is accelerating.
The GLP-1 era is fundamentally transforming how Americans approach weight loss and nutrition. Unlike restrictive diets that eventually end, many users remain on these medications for months or years, creating sustained demand for companion supplements that fill nutritional gaps and improve quality of life.
For supplement brands, this represents a rare opportunity: a massive, growing consumer base with clearly defined needs and willingness to invest in supporting products. The brands that succeed will be those that:
The GLP-1 companion supplement category offers tremendous potential for brands ready to serve this market responsibly. Whether you’re launching your first product or expanding an existing line, Health Genesis provides the formulation expertise, manufacturing capability, and regulatory guidance to bring your vision to market.
This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new supplement regimen.
Ready to explore custom formulations for GLP-1 companion supplements?
Contact Health Genesis today to discuss how we can help you create compliant, effective products that meet the needs of this fast-growing consumer segment. From initial concept through manufacturing and fulfillment, we’re your partner in building brands that matter.
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